THE REACTION OF SUBSTITUTED BENZOYLISOTHIOCYANATES WITH METHIONINE AND STUDY OF THE ANTI–INFLAMMATORY ACTIVITY OF THE SYNTHESIZED COMPOUNDS
Ключевые слова:
thiourea, benzoyl isothiocyanate, α-Amino acids, methionine, methionylthiourea Inflammation, anti-inflammatory activitiesАннотация
Abstract: The thiourea derivatives were synthesized by the reaction of substituted benzoyl isothiocyanates and α–amino acid – methionine in a dimethylformamide medium. The anti– inflammatory activity of the obtained compounds was studied. It has been established that N– (meta–iodobenzoyl) –NI–methionylthiourea has a much greater latitude of anti–inflammatory action and is of undoubted practical interest.
